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Biomechanics of synthetic elastin : insights from Magnetic Resonance microimaging

By Konstantin I. Momot, Sean K. Powell, Suzanne M. Mithieux and Anthony S. Weiss


We used Magnetic Resonance microimaging (μMRI) to study the compressive behaviour of synthetic elastin. Compression-induced changes in the elastin sample were quantified using longitudinal and transverse spin relaxation rates (R1 and R2, respectively). Spatially-resolved maps of each spin relaxation rate were obtained, allowing the heterogeneous texture of the sample to be observed with and without compression. Compression resulted in an increase of both the mean R1 and the mean R2, but most of this increase was due to sub-locations that exhibited relatively low R1 and R2 in the uncompressed state. This behaviour can be described by differential compression, where local domains in the hydrogel with a relatively low biopolymer content compress more than those with a relatively high biopolymer content

Topics: 029901 Biological Physics, Tropoelastin, biomaterials, magnetic resonance imaging, spin relaxation, biomechanics of soft tissues, elasticity, entropic model of biopolymer deformation
Publisher: Trans Tech Publications, Switzerland
Year: 2013
DOI identifier: 10.4028/
OAI identifier:

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