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Inhibition of guinea-pig renal [Na + K]-ATPase by normotensive human plasma : effects of a high sodium diet

By R. M. Wellard, J. B. Myers, J. A. Danks, T. O. Morgan and W. R. Adam


The effect of plasma taken from normotensive humans, while on a low and high sodium diet, on [Na + K]-ATPase and 3H-ouabain binding was measured in tubules from guinea-pig kidneys. Plasma from the high sodium, compared to the low sodium, diet period: (a) inhibited [Na + K]-ATPase activity; (b) decreased 3H-ouabain affinity for binding sites; (c) increased the number of available 3H-ouabain binding sites; (d) decreased [Na + K]-ATPase turnover (activity/3H-ouabain binding sites). The inhibition of [Na + K]-ATPase suggests an increase in a (possible) natriuretic factor. The decreased affinity of 3H-ouabain binding suggests an endogenous ouabainoid, which may be the natriuretic factor

Topics: 060600 PHYSIOLOGY, 110200 CARDIOVASCULAR MEDICINE AND HAEMATOLOGY, 111103 Nutritional Physiology, hypertension, kidney, [Na + K]-ATPase, ouabain, natriuretic factor, sodium
Publisher: Wiley-Blackwell Publishing Asia
Year: 1983
DOI identifier: 10.1111/j.1440-1681.1983.tb00193.x
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