Article thumbnail
Location of Repository

Inhibition of guinea-pig renal [Na + K]-ATPase by normotensive human plasma : effects of a high sodium diet

By R. M. Wellard, J. B. Myers, J. A. Danks, T. O. Morgan and W. R. Adam

Abstract

The effect of plasma taken from normotensive humans, while on a low and high sodium diet, on [Na + K]-ATPase and 3H-ouabain binding was measured in tubules from guinea-pig kidneys. Plasma from the high sodium, compared to the low sodium, diet period: (a) inhibited [Na + K]-ATPase activity; (b) decreased 3H-ouabain affinity for binding sites; (c) increased the number of available 3H-ouabain binding sites; (d) decreased [Na + K]-ATPase turnover (activity/3H-ouabain binding sites). The inhibition of [Na + K]-ATPase suggests an increase in a (possible) natriuretic factor. The decreased affinity of 3H-ouabain binding suggests an endogenous ouabainoid, which may be the natriuretic factor

Topics: 060600 PHYSIOLOGY, 110200 CARDIOVASCULAR MEDICINE AND HAEMATOLOGY, 111103 Nutritional Physiology, hypertension, kidney, [Na + K]-ATPase, ouabain, natriuretic factor, sodium
Publisher: Wiley-Blackwell Publishing Asia
Year: 1983
DOI identifier: 10.1111/j.1440-1681.1983.tb00193.x
OAI identifier: oai:eprints.qut.edu.au:51367
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • https://eprints.qut.edu.au/513... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.