doi:10.1152/japplphysiol.00950.2013.—We tested the hypothesis that neuromechanical uncoupling of the respiratory system forms the mechanistic basis of dyspnea during exercise in the setting of “ab-normal ” restrictive constraints on ventilation (VE). To this end, we examined the effect of chest wall strapping (CWS) sufficient to mimic a “mild ” restrictive lung deficit on the interrelationships between VE, breathing pattern, dynamic operating lung volumes, esophageal elec-trode-balloon catheter-derived measures of the diaphragm electro-myogram (EMGdi) and the transdiaphragmatic pressure time product (PTPdi), and sensory intensity and unpleasantness ratings of dyspnea during exercise. Twenty healthy men aged 25.7 1.1 years (means SE) completed symptom-limited incremental cycle exercise tests under two randomized conditions: unrestricted control and CWS to reduce vital capacity (VC) by 21.6 0.5%. Compared with control, exercise with CWS was associated with 1) an exaggerated EMGdi an
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