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Polycaprolactone-based scaffold plus rhBMP-2 in a sheep thoracic spine fusion model

By Mostyn Yong, Ferry P.W. Melchels, Cedryck Vaquette, Dietmar Hutmacher, Clayton J. Adam, Marco Domingos and Paulo J. Bartolo

Abstract

We report the application of a novel scaffold design in a sheep thoracic spine model for spine deformity correction. The combination of the calcium-phosphate coated polycaprolactone scaffolds with recombinant human bone morphogenic protein-2 (rhBMP-2) are intended as a future bone graft substitute in ensuring the stability of bony intervertebral fusion. A solid free-form fabrication process based on melt extrusion has been utilized in the manufacturing of these scaffolds. To date there are no studies examining the use of such biodegradable implants in a sheep thoracic spine model. The success of anterior scoliosis surgery in humans depends on achieving a solid bony fusion between adjacent vertebrae after the intervertebral discs have been surgically cleared and the disc spaces filled with graft material. Due to limited availability of autograft, there is much current interest in the development of synthetic scaffolds in combination with growth factors such as recombinant human bone morphogenetic protein (rhBMP-2) to achieve a solid bony fusion following scoliosis surgery

Topics: 090300 BIOMEDICAL ENGINEERING, 090304 Medical Devices, 110314 Orthopaedics, biodegradable scaffold, polycaprolactone scaffold, intervertebral fusion, spinal deformity, bone morphogenetic protein, sheep thoracic spine
Publisher: CRC Press/Balkema
Year: 2012
DOI identifier: 10.1201/b11341-16
OAI identifier: oai:eprints.qut.edu.au:47835

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