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Application of micro CT and computation modeling in bone tissue engineering

By Barnabas Ho Saey Tuan and Dietmar Hutmacher


Computer aided technologies, medical imaging, and rapid prototyping has created new possibilities in biomedical engineering. The systematic variation of scaffold architecture as well as the mineralization inside a scaffold/bone construct can be studied using computer imaging technology and CAD/CAM and micro computed tomography (CT). In this paper, the potential of combining these technologies has been exploited in the study of scaffolds and osteochondral repair. Porosity, surface area per unit volume and the degree of interconnectivity were evaluated through imaging and computer aided manipulation of the scaffold scan data. For the osteochondral model, the spatial distribution and the degree of bone regeneration were evaluated. In this study the versatility of two softwares Mimics (Materialize), CTan and 3D realistic visualization (Skyscan) were assessed, too.\ud \u

Topics: 069900 OTHER BIOLOGICAL SCIENCES, 090300 BIOMEDICAL ENGINEERING, 091300 MECHANICAL ENGINEERING, 111600 MEDICAL PHYSIOLOGY, 120300 DESIGN PRACTICE AND MANAGEMENT, Computer aided design; Medical imaging; Scaffolds; Bone engineering; Micro CT
Publisher: Pergamon
Year: 2005
DOI identifier: 10.1016/j.cad.2005.02.006
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