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Brief communication Anti-DNA antibodies in discoid lupus erythematosus Follow-up study

By Barry Bresnihan, Graham and R. V. Hughes


SUMMARY Anti-DNA antibodies have been detected previously in patients with chronic discoid lupus erythematosus (DLE) despite the absence of overt systemic manifestations. 27 patients with DLE were followed up 3 years after the detection of anti-DNA antibodies in 7. None had developed other features of systemic lupus erythematosus. We conclude that the occasional finding of anti-DNA antibodies in patients with DLE does not predict those likely to develop systemic disease. The detection of serum anti-DNA antibodies is an important adjunct to the investigation and manage-ment of patients with systemic lupus erythematosus (SLE) (Hughes, 1971). In the absence of systemic disease, patients with chronic discoid lupus ery-thematosus (DLE) usually do not have anti-DNA antibodies (Prystowsky et al., 1976). However, some studies using sensitive techniques have reported the presence of anti-DNA antibodies in a proportion of patients with DLE (Mandel etal., 1972; Sylvester e

Year: 2016
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