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t-10,c-12 CLA dietary supplementation inhibits atherosclerotic lesion development despite adverse cardiovascular and hepatic metabolic marker profiles. PLoS One 2012

By Patricia L. Mitchell, Tobias K. Karakach, Deborah L. Currie and Roger S. Mcleod


Animal and human studies have indicated that fatty acids such as the conjugated linoleic acids (CLA) found in milk could potentially alter the risk of developing metabolic disorders including diabetes and cardiovascular disease (CVD). Using susceptible rodent models (apoE2/2 and LDLr2/2mice) we investigated the interrelationship between mouse strain, dietary conjugated linoleic acids and metabolic markers of CVD. Despite an adverse metabolic risk profile, atherosclerosis (measured directly by lesion area), was significantly reduced with t-10, c-12 CLA and mixed isomer CLA (Mix) supplementation in both apoE2/2 (p,0.05, n = 11) and LDLr2/2 mice (p,0.01, n = 10). Principal component analysis was utilized to delineate the influence of multiple plasma and tissue metabolites on the development of atherosclerosis. Group clustering by dietary supplementation was evident, with the t-10, c-12 CLA supplemented animals having distinct patterns, suggestive of hepatic insulin resistance, regardless of mouse strain. The effect of CLA supplementation on hepatic lipid and fatty acid composition was explored in the LDLr2/2 strain. Dietary supplementation with t-10, c-12 CLA significantly increased liver weight (p,0.05, n = 10), triglyceride (p,0.01, n = 10) and cholesterol ester content (p,0.01, n = 10). Furthermore, t-10, c-12 CLA also increased the ratio of 18:1 to 18:0 fatty acid in the liver suggesting an increase in the activity of stearoyl-CoA desaturase. Changes in plasma adiponectin and liver weight with t-10, c-12 CLA supplementation were evident within 3 weeks of initiation of the diet. These observations provide evidence that the individual CLA isomer

Topics: Adverse Cardiovascular and Hepatic Metabolic Marker Profiles. PLoS ONE 7(12, e52634. doi, 10.1371/journal.pone.0052634
Year: 2016
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