Article thumbnail

Increased Inflammatory Markers and Endothelial Dysfunction are Associated with Variant Angina

By 

Abstract

Background and Objectives:Endothelial dysfunction and increased vascular inflammation may be associated with variant angina (VA). However, their exact roles remain to be clarified. The aim of the presents study is to investigate whether the level of inflammation markers and the flow-mediated dilation (FMD) are related to VA. Subjects and Methods:The study included 46 patients (VA group: 53.9±12.0 years, 20 males) with positive spasm provocation tests and they were without significant coronary stenosis, and 14 patients (control group: 46.6±13.5 years, 7 males) with negative spasm provocation tests and they were without significant coronary stenosis. The clinical characteristics and inflammatory markers, including the high sensitive C-reactive protein (hsCRP) level, the monocyte count and the von Willebrand factor (vWF) level, and the FMD were compared between the two groups. The FMD and inflammatory markers were measured in the morning before performing the ergonovine provocation coronary angiogram. Results:The level of vWF was significantly higher in the VA group than in the control group (166.5±41.9 % vs. 118.0±65.3%, respectively, p=0.029). The FMD was significantly decreased in the VA group compared with the control group (9.2±4.3 % vs. 12.4±4.2%, respectively, p=0.021). Nitrate-mediated dilation did not differ between the two groups. The levels of the monocyte count, hs-CRP and homo

Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.951.8136
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://synapse.koreamed.org/Sy... (external link)
  • http://synapse.koreamed.org/Sy... (external link)
  • http://citeseerx.ist.psu.edu/v... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.