Skip to main content
Article thumbnail
Location of Repository

State, trait and biochemical influences on human anterior cingulate function

By Murat Yucel, Ben J. Harrison, Stephen J. Wood, Alex Fornito, Kerrie Clarke, R. Mark Wellard, Sue Cotton and Christos Pantelis


The dorsal part of the human anterior cingulate cortex (dACC) is reliably activated in situations requiring cognitive control, especially during states of conflict. However, little is known about how individual differences in the neural characteristics of the dACC and major dimensions of behavior, affect this brain response. We recruited 28 healthy adults and employed a multi-modal neuroimaging approach combined with a task designed to specifically activate the human dACC and statistical path analysis to demonstrate clear roles for intelligence, personality and concentrations of neuronal N-acetylaspartate in determining dACC activation. These influences were comparable in magnitude to those associated with the experience of conflict. Our findings extend current understandings of the neural substrates of cognitive control by modeling the effect of neuronal viability, intelligence, and personality, on dACC activation. They also highlight the importance of considering enduring personal characteristics when mapping human brain-behavior relationships

Topics: 110319 Psychiatry (incl. Psychotherapy), 170101 Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology), 060104 Cell Metabolism, 170205 Neurocognitive Patterns and Neural Networks, 111601 Cell Physiology, 060603 Animal Physiology - Systems, 170112 Sensory Processes Perception and Performance, 110903 Central Nervous System, 110902 Cellular Nervous System, 060105 Cell Neurochemistry, 100402 Medical Biotechnology Diagnostics (incl. Biosensors), 110904 Neurology and Neuromuscular Diseases, 111714 Mental Health
Publisher: Elsevier
Year: 2007
DOI identifier: 10.1016/j.neuroimage.2006.08.057
OAI identifier:
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.