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Prostaglandin-inhibitor naproxen does not affect contact lens-induced changes in the human corneal endothelium

By Nathan Efron, Brien A. Holden and Antti Vannas


A randomized, double-masked, placebo-controlled study was conducted to determine the effect of the prostaglandin-inhibitor naproxen on the bleb response of the corneal endothelium during hydrogel contact lens wear. Naproxen did not significantly alter the bleb response. This finding suggests that the endothelial bleb response is not prostaglandin-mediated

Topics: 111300 OPTOMETRY AND OPHTHALMOLOGY, Prostaglandin Antagonists, Contact Lenses/, adverse effects, Cornea/, pathology, Naproxen/, therapeutic use, Adolescent, Adult, Endothelium/pathology, Evaluation Studies, Female, Humans, Male
Publisher: Lippincott Williams & Wilkins
Year: 1984
DOI identifier: 10.1097/00006324-198412000-00004
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