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New Cholinesterase Inhibitor, Lipoic Acid-Nitrone Derivatives

By Yun Mi Seo, Kang Hee Nam, Pill Seong Kang, Sung Bo Ko, Eugene Oh, Min Tae Sung, Byoung Wook Choi, Bong Ho Lee and Jeong Ho Park


Lipoic acid (LA) is a multifunctional antioxidant against a variety of ROS. Nitrone acts as free radical spin trap and exhibits neuroprotective activity. Thus, LA-nitrone derivatives (6, 7, 8, and 9) were synthesized and screened as an antioxidant and inhibitors for cholinesterases. Even though the antioxidant effect of LA-nitrone derivatives was not improved, they turned out to be effective inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) in μM range

Topics: Key Words, Lipoic acid, Nitrone, Antioxidant, Cholinesterase inhibitor
Year: 2006
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