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The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells

By Kazuyuki Hosokawa, Philip Chen, Martin Lavin and Steven E. Bottle


Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation survival rates of ataxia telangiectasia (A-T) cells compared to normal cells, an assay which represents a model for understanding the impact of ROS damage on the A-T phenotype. The effects of these antioxidants are much more significant than those of vitamin E or Trolox (a water-soluble vitamin E analog), studied using the same cell survival mode

Topics: 030000 CHEMICAL SCIENCE, Nitroxide, Ataxia telangiectasia, Antioxidant, ROS, Free radical, Oxidative stress
Publisher: Elsevier
Year: 2004
DOI identifier: 10.1016/j.freeradbiomed.2004.06.035
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