In a prospective study, we have investigated the effect of lens care system instructions on the rate of compliance of 44 subjects who each used three different lens care systems (cross-over design), each system for a two week period. All three lens care system instructions recommended hand washing prior to lens handling, a daily cleaning procedure, a daily disinfection procedure, but varied in the recommended frequency of case cleaning. Compliance was assessed by observing the subject's normal care routine at an aftercare consultation and by questioning the subject. The compliance with daily cleaning and disinfection procedures was high throughout the six weeks. Compliance with hand washing instructions was initially relatively poor, but improved over time. The frequency of case cleaning was significantly influenced by the lens care system instructions and by patient-specific factors. Compliance was not significantly influenced by the optometrist delivering lens care instructions, however, with some aspect of compliance this association approached statistical significance
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