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Correspondence Letter by Nakajima and Saito Regarding Article, “Human C-Reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits” To the Editor:



Koike et al1 recently reported in Circulation that the transgenic expression of human C-reactive protein (CRP) in rabbits fed a cholesterol-rich diet did not promote the pathogenesis of atheroscle-rosis despite its detection in atherosclerotic plaque. This result supports some animal studies cited in the article and several epidemiological studies that indicate no associations between ele-vated circulating CRP and cardiovascular disease.2 However, in clinical practice, CRP is often elevated in people with excess visceral fat, independent of genetic influences,3 and predisposes them to critical metabolic dysfunctions related to insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome (MetS). Although glucose metabolism in the transgenic rabbit was not fully described, the rabbits are unlikely to have had abnormal glucose metabolism and insulin resistance given the blood parameters reported in the supplemental data. In addition, although the transgenic rabbits wer

Year: 2016
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