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Novel markers of peripheral arterial disease

By Farhan J Khawaja


Abstract: Peripheral arterial disease (PAD), a relatively common manifestation of ath-erosclerotic vascular disease, is associated with significant morbidity and mortality. Although conventional risk factors contribute to the onset and progression of PAD, the role of ‘novel ’ biomarkers in pathways of inflammation, thrombosis, lipoprotein metabolism, and oxidative stress in determining susceptibility to PAD is being increasingly recognized. Validation of novel risk factors for PAD may allow earlier detection, an improved understanding of disease etiology and progression, and the development of new therapies. In this review, we discuss available evidence for asso-ciations between novel circulating markers and several aspects of PAD including dis-ease susceptibility, progression, functional limitation, and adverse outcomes

Topics: inflammation, peripheral arterial disease, risk factors
Year: 2009
DOI identifier: 10.1177/1358863x09106869
OAI identifier: oai:CiteSeerX.psu:
Provided by: CiteSeerX
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