unique in that they replicate DNA by transposition (for review, see Toussaint and Resibois 1983). During lytic growth, about 100 new viral copies are placed ran-domly in the host chromosome. These viruses also in-tegrate linearly into the chromosome and establish a lysogenic state by producing a repressor. Their ability to change efficiently from the integrated stable state of the lysogen to the rapid replicative cycle makes them powerful systems for biochemical analysis of transposition. The transition from a lysogenic state to the lytic cycle requires activation of a Mu promoter and synthesis of Mu-encoded proteins. To understand the early events in this transition, we have studied the Mu repressor and the early transposition reaction products. Purifie
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