Abstract. Three neoplasms of extracutaneous mast-cell origin, arising from the nasophar-ynx, oral cavity, and hepatopancreatic lymph nodes respectively, were diagnosed in three dogs. The neoplasms had histologic features similar to those of cutaneous mast-cell tumors, but had limited metastasis mostly involving the regional lymph nodes. One dog had a perforating duodenal ulcer, suggesting that duodenal ulcers can occur with extracutaneous tumors as they do with some cutaneous mast-cell tumors in the dog. Neoplasms of mast-cell origin usually affect the skin, and are among the most common cutaneous neoplasms in the dog [6, 101. In 76 % of these tumors the regional lymph nodes, and less commonly other visceral organs, become involved secondarily . Primary sites of canine mast-cell tumor other than the skin, including the oral cavity [3, 5, 121 and larynx [l], have been reported rarely, and a mast-cell tumor arising from the intestines of a dog has been described recently [ 1 11. Focal mast-cell infiltration involving more than one lymph node in a dog has been reported, and was considered a benign accumulation of mast cells in the lymph nodes . We describe three mast-cell tumors arising from three different extracutaneou
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