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Printed in U.8.A. LIVER GROWTH ASSOCIATED WITH THE INDUCTION OF AMINOPYRINE DEMETHYLASE ACTIVITY AFTER PHENOBARBITAL TREATMENT IN ADULT

By Male Rats and Thomas S. Argyris

Abstract

ABsTRACT Aaoais, THOMAS S.: Liver growth associated with the induction of aminopyrine demethylase activity after phenobarbital treatment in adult male rats. 3. Pharmacol. Exp. Ther. 164: 405-411, 1968. Five daily injections of 100 mg/kg b.wt. of phenobarbital into young adult male rats results in a marked increase in the arninopyrine demethylase activity. Associated with the increase in aminopyrine demethylase is a marked increase in liver weight and total protein. There is also an increase in the total deoxyribonucleic acid and ribonucleic acid, but not in the nuclear count. The hepatocyte mitotic activity is greatly increased during the first 4 days of phenobarbital injection. The injection of phenobarbital into rats re-suits not only in an increase in the drug-metab-olizing enzyme activity of the liver but also in an increase in liver weight and total protein (for reviews, see Conney, 1967; Conney and Burns, 1962). In immature male rats the role o

Year: 1968
OAI identifier: oai:CiteSeerX.psu:10.1.1.934.9
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