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Host Reactive Donor T Cells Are Associated With Lung Injury After Experimental

By Allogeneic Bone Marrow Transplantation, R. Cooke, Werner Krenger, Geoff Hill, Thomas R. Martin, Lester Kobzik, Joanne Brewer, Raymond Simmons, James M. Crawford and James L. M. Ferrara


Noninfectious lung injury is common after allogeneic bone marrow transplantation (BMT), but its association with acute graft-versus-host disease (GVHD) is unclear. Using a murine BMT system where donor and host differ by multiple minor histocompatibility (H) antigens, we investigated the nature of lung injury and its relationship both to systemic GVHD and host-reactive donor T cells. Lethally irradiated CBA hosts received syngeneic BMT or allogeneic (B10.BR) T-cell–depleted (TCD) bone marrow (BM) with and without the addition of T cells. Six weeks after BMT, significant pulmonary histopathology was observed in animals receiv-ing allogeneic BMT compared with syngeneic controls. Lung damage was greater in mice that received allogeneic T cells and developed GVHD, but it was also detectable after TCD BMT when signs of clinical and histologic acute GVHD wer

Year: 2016
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