Article thumbnail
Location of Repository

The Therapeutic Impact of The Ethanolic Leaf Extract of Vernonia Amygdalina on Castor Oil Induced Diarrhoea in Wistar Albino Rats Authors

By Chibuzor O. Okonkwo, Corresponding Chibuzor and O. Okonkwo

Abstract

The effect of the ethanolic leaf extract of Vernonia amygdalina (bitter leaf) on castor oil induced diarrhoea in waster albino rats was analysed using loperamide 0.006mg/100g body weight as a reference standard. The result showed that Vernonia amygdalina exhibited a dose dependent, significant (p˂0.05) anti-diarrhoeal activity against the castor oil induced diarrhea. The mean weight of faeces for the positive control (loperamide), the negative control (normal saline), 20mg/100g body weight and 40mg/100g body weight of the leaf extract were: 1.10 ± 0.12, 3.08±0.25, 2.45 ± 0.25, and 2.12 ± 0.28, respectively. The mean number of faecal drops was: 1.0 ±1.14, 6.0±2.0, 3.25±1.64, and 2.50±0.54 respectively. The percentage inhibitions were: 64.28%, for lopermide, 20.45 % for the extract at 20mg/100g body weight and 31.16%, at 40mg/100g body weght. This shows that the ethanolic leaf extract of Vernonia amygdalina may contain pharmacologically active substance(s) with anti-diarrhoeal efficacy

Topics: Therapeutic, Impact, Induce, Diarrhoea, Castor oil, Vernonia amygdalina
Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.932.4975
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://ijsae.in/ijsaeems/index... (external link)
  • http://ijsae.in/ijsaeems/index... (external link)
  • http://citeseerx.ist.psu.edu/v... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.