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Letters to the Editor-in-Chief



The role of Apex2 in class-switch recombination of immunoglobulin genes To the Editor-in-Chief, In the recent publication titled ‘Apex2 is required for efficient somatic hypermutation but not for class switch recombina-tion ’ by Sabouri et al. (1), the authors reached conclusions opposite to that which we published in the Journal of Experi-mental Medicine in 2007 (2). Sabouri et al. showed that IgA switching in the CH12F3-2 cell line was not affected by Apex1 knockdown by siRNA and that class switching to IgG1 in Apex2-deficient and control splenocytes was equally efficient. The authors concluded that Apex1 and Apex2 are not required for immunoglobulin class switching and sug-gested that the culture conditions might be at the basis of this discrepancy. To study the role of Apex2 in class switch

Year: 2016
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