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To the Editor: Matrix metalloproteinases (MMPs)

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Abstract

are calcium/zinc-dependent endo-proteinases involved in physiologic and pathologic processes, modulat-ing extracellular matrix degradation (1). MMP-2 (EC 3.4.24.24) and MMP-9 (EC 3.4.24.35) circulating in the peripheral blood (PB) of patients with neoplasia showed contrasting results, revealing the preanalytical issue of whether the method of PB sampling influences MMP concentra-tions (2) and their zymographic pro-files (3). We therefore analyzed the effects of anticoagulants and cell sep-aration media on PB gelatinolyti

Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.929.4716
Provided by: CiteSeerX
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