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To the Editor: Matrix metalloproteinases (MMPs)



are calcium/zinc-dependent endo-proteinases involved in physiologic and pathologic processes, modulat-ing extracellular matrix degradation (1). MMP-2 (EC and MMP-9 (EC circulating in the peripheral blood (PB) of patients with neoplasia showed contrasting results, revealing the preanalytical issue of whether the method of PB sampling influences MMP concentra-tions (2) and their zymographic pro-files (3). We therefore analyzed the effects of anticoagulants and cell sep-aration media on PB gelatinolyti

Year: 2016
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