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Author’s Response to Commentary Cell Senescence: An Evaluation of Replicative Senescence in Culture as a Model for Aging In Situ

By James R. Smith


We recently published a study (1) in which we used colony size distribution (CSD) to estimate the in vitro proliferative potential of a large number of male and female donors aged 19–90þ years of age. In a commentary pub-lished in this issue of the Journal, Cristofalo and colleagues (2) have commented on some differences between the data and interpretation presented in our report and those of other authors. In this article, we respond to those comments in the order in which they were presented. First, Cristofalo and colleagues ‘‘suggest that CSD is not useful as a method for estimating total replicative life span’’ (2). This observation is based primarily on the failure of the authors to find a significant relationship between the esti-mated in vitro life span, which we calculated using CSD, and the proliferative potential obtained by technicians at th

Year: 2016
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