usually occurs in childhood, serological investigations show that primary infection with this virus or ac-tivation of latent infection is common in adults too (1, 2). Most infections in adults are clinically inap-parent. In contrast to earlier assumptions, at present there is good evidence that even in previously healthy adults cytomegalovirus infection can occasionally give rise to a great variety of clinical symptoms. In this issue Jordan and others (p. 153) report interesting clinical and laboratory observations on nine patients with "spontaneous " cytomegalovirus mononucleosis, who had no history of pre-illness blood transfusions or surgery. This syndrome, first described in 1965 (3) and probably caused by pri-mary cytomegalovirus infection, is characterized b
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