10.1677/joe.0.0410453

PREVENTION BY NANDROLONE DECANOATE OF DEXAMETHASONE-INDUCED MITOTIC INHIBITION IN MOUSE EAR EPIDERMIS IN VITRO

Abstract

Steroids with glucocorticosteroid activity have been widely used as anti-inflam-matory agents in the skin. The disadvantages are that such substances may reduce resistance to infection, although this may be countered by antiseptics or anti-biotics, and that they may inhibit the healing of damaged tissues. The question arises whether it is possible to counteract the inhibition of healing without also suppressing the anti-inflammatory action. One basic feature of the healing process in inflamed skin is the production of new cells by mitosis, and the mitotic rate can be used as a measure of the healing activity. It is well known that relatively high concentrations of glucocorticosteroid hormones can inhibit normal epidermal mitotic activity (see Bullough, 1965), and such high concentrations are certainly reached during topical treatment. In the present investigation an attempt has been made to prevent the dexametha-sone-induced mitotic inhibition in normal epidermis by coincident treatment with nandrolone decanoate which was chosen because it is an active anabolic steroid. To avoid variations in hormone concentration (especially of adrenaline: Bullough &amp

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oai:CiteSeerX.psu:10.1.1.923.1812Last time updated on 11/1/2017

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