Trichinella spiralis shares epitopes with human autoantigens

Abstract

Like other helminths, Trichinella spiralis has evolved strategies to allow it to survive in the host organism, in-cluding the expression of epitopes similar to those present in either expressed or hidden host antigens. To identify T. spiralis-derived antigens that are evolutionarily conserved in the parasite and its host and that could be responsible for its evasion of the host immune response, we examined the reactivity of six different types of autoantibodies to T. spiralis larvae from muscle. T. spiralis antigens that share epitopes with human autoantigens were identified by assessing the cross-reactivity of autoantibody-containing serum samples with T. spiralis antigens in the absence of specific anti-parasite antibodies. Of the 55 autoantibody-containing human serum samples that we analysed by im-munohistological screening, 24 (43.6%) recognised T. spiralis muscle larvae structures such as the subcuticular re-gion, the genital primordium or the midgut. Using Western blots, we demonstrated that the same sera reacted with 24 protein components of T. spiralis muscle larvae excretory-secretory L1 antigens. We found that the human autoanti-bodies predominantly bound antigens belonging to the TSL1 group; more specifically, the autoantibody-containing sera reacted most frequently with the 53-kDa component. Thus, this protein is a good candidate for further studies of the mechanisms of T. spiralis-mediated immunomodulation. Key words: human autoantibodies- Trichinella spiralis antigens- conserved epitopes The immune system, which evolved to detect, inac

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oai:CiteSeerX.psu:10.1.1.919.3926Last time updated on 11/1/2017

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