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Risk Factors and Clinical Outcomes for Vancomycin-Resistant Enterococcus Colonization on Intensive Care Unit Admission

By Sook-jin Kang


Purpose: The purpose of this study was to identify vancomycin-resistant enterococcus (VRE) colonization rate in patients ad-mitted to the intensive care unit (ICU), associated risk factors and clinical outcomes for VRE colonization. Methods: Of the 7,703 patients admitted to the ICUs between January, 2008 and December, 2010, medical records of 554 VRE colonized and 503 un-colonized patients were reviewed retrospectively. To analyzed the impact of colonization on patients ’ clinical outcomes, 199 VRE colonized patients were matched with 199 uncolonized patients using a propensity score matching method. Results: During the study period, 567 (7.2%) of the 7,703 patients were colonized with VRE. Multivariate analysis identified the following indepen-dent risk factors for VRE colonization: use of antibiotics (odds ratio [OR]=3.33), having bedsores (OR=2.92), having invasive de-vices (OR=2.29), methicillin-resistant Staphylococcus aureus co-colonization (OR=1.84), and previous hospitalization (OR=1.74). VRE colonized patients were more likely to have infectious diseases than uncolonized patients. VRE colonization was associated with prolonged hospitalization and higher mortality. Conclusion: Strict infection control program including pre-emptive isolation for high-risk group may be helpful. Further research needs to be done to investigate the effects of active sur-veillance program on the incidence of colonization or infection with VRE in the ICU

Year: 2016
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