(IHC) Approach Analyzed with Automated Tissue and Cell


Liver resection is the most effective treatment for primary or metastatic liver tumors. The extent of liver resection is restricted by the minimum volume of liver remnant required to provide sufficient postoperative liver function. Preopera-tive portal vein embolization (PVE) is an option to increase future remnant liver (FRL) volume through induction of regeneration of the hepatocellular mass of the FRL (de Graaf et al. 1998). Following occlusion of the right or left branch of the portal vein, atrophy of the embolized liver segments occurs, whereas hyperplasia of the contralateral, non-embolized liver lobe is induced. In our group, we study the effects of PVE of the liver in different circumstances in a rabbit model as developed by de Graaf et al. (2011; van den Esschert et al. 2011). One of the parameters of interest in this model is the Ki67 proliferation index in both the embolized and non-embolized liver lobes in different research settings. However, one of the difficulties we encountered was the presence of non-parenchymal cells, such as leucocytes in the sinusoidal space of the liver, which 461154 JHCXXX10.1369/0022155412461154van der Loos et al.Quantitation of Proliferating Hepatocyte

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