We describe the parameters that can influence the outcome of severe closed craniocerebral injury. Craniocerebral injuries involve two phas-es: the phase of primary injury, which includes primary cerebral le-sions made under the influence of factors that have a direct or indirect impact on the cranium, and the phase that represents secondary inju-ries, which are the result of the impact of pathophysiological mecha-nisms (hypoxia, hypercapnia, and hypotension). These mechanisms are initiated by a trauma as well as some specific characteristics of the organism (e.g., age, comorbid conditions, and previous injuries). The aim of the study was to establish factors that significantly influence the outcome after severe closed craniocerebral injury. A total of 182 pa-tients that were treated at the Clinical Center in Kragujevac from 2001 to 2005 were included. The most important prognostic factors for the treatment outcome were: age, oxygen saturation, the Glasgow Coma Scale score (GCS) and level of injury of the cerebral tissue diagnosed by a CT. Morbidity risk raised by 2.6 % when only the age parameter increased by one year. When evaluating a 1 % increase in oxygen satu-ration, the morbidity risk rate fell for 10.7 % of the patients if other pa-rameters remained stable. According to the aforementioned criteria, a 159.3 % increase in morbidity risk rate was observed between mild and severe brain injury when other parameters did not change. In conclusion, a severe closed cerebrocranial injury is a dominant factor for the determination of patient outcome

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