DISTRIBUTION AND EXCRETION OF RADIOACTIVITY IN RATS RECEIVING N-METHYL-C”- ERYTHROMYCIN

Abstract

In a previous communication (Lee et al., l953-l954a), we reported that approximately one half of a single intravenously injected dose of erythromycin was recovered in the hepatic bile and urine in six hours. Tissue distribution studies indicated that erythromycin was concentrated in liver, spleen, pancreas, kidney, adrenals, submaxillary glands and lungs in the dog (Lee et al., 1953-l954a) and the rat (Lee et at., 1953). Determination of erythromycin in these experiments was based upon its biological activity (Higgens et al., 1953; Ziegler and McGuire, 1953). Therefore, our knowledge of the tissue distribution and excretion of erythromycin was very limited, and little was known of that frac-tion of the administered erythromycin which could not be recovered. The syn-thesis of N-methyl-C”-erythromycin (Flynn et al., 1955) has made it possible to follow the erythromycin metabolism in the body by means of tracer technics. In this communication, tissue distribution and excretion of carbon-14 in rats that received N-methyl-C’4-erythromycin are reported. METHODS AND MATERIALS. Isotopic Erythromycin: N-methyl-C”-erythromycin ’ used i

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oai:CiteSeerX.psu:10.1.1.913.7956Last time updated on 11/1/2017

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