ARTICLE Multiple Roles of Cyclin-Dependent Kinase 4/6 Inhibitors in Cancer Therapy


Cyclin-dependent kinases (CDKs) mediate cell cycle progression, regulating transition from G1 to S phase and G2 to M phase. CDK activity is tightly controlled throughout the cell cycle by posttran-scriptional modifications as well as the expression of cyclins and CDK inhibitors. There are four proliferative CDKs: CDK1, which predominantly regulates the transition from G2 to M phase, and CDK2/4/6, which regulate the transition from G1 to S phase (1,2). Recent work has shown that there is considerable redun-dancy among the CDKs that regulate the transition from the G1 to S phase, and many proliferating cells can use any of thes

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