ON THE MODE OF ACTION OF THE SULFONAMIDES III. PURINES, AMINO ACIDS, PEPTONES AND PANCREAS AS ANTAGONISTS AND POTENTIATORS OF SULFONAMIDE IN E. COLI

Abstract

Using strains of Escherichia coli which grow in simple synthetic media, Bliss and Long (1) and we (2, 3) independently showed that methionine has appreci-able antisulfonamide activity. Bliss and Long also reported that arginine and lysine irregularly showed slight antisulfonamide action. In the case of our strain, no other amino acid per se is antagonistic, though some including ethionine are inhibitory. However, if methionine is already present in the medium, then glycine, serine, and allothreonine become antagonistic (4). It was also re-ported briefly (5) that certain purines can potentiate or antagonize the sul-fonamides. Although the individual actions of the foregoing agents are not great compared to that of p-aminobenzoic acid (6), their effects are additive and thus may reach significant levels. The question, therefore, arises whether they can ac-count for the antisulfonamide activity of peptones (7, 8) and other biological materials (8, 9). If they can not, either alone or with p-aminobenzoic acid, then other inhibitory agents yet to be discovered must reside in these preparations

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oai:CiteSeerX.psu:10.1.1.904.7752Last time updated on 11/1/2017

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