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Dorsal root ganglion neurons maintained in a 3D culture model exhibit similar electrophysiological properties to fresh explants

By E. East, K. Murphy and J. Phillips


Tissue engineered culture models provide a powerful tool for neuroscience research1. They overcome limitations associated with monolayer cultures of neurons and glia by maintaining cells in a more realistic 3D spatial arrangement, and permit continuous monitoring and control of variables that cannot be achieved in animal models. Here we report the development of a system for recording electrophysiological behaviour in neurons in 3D culture

Year: 2011
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Provided by: Open Research Online

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