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Cytochrome bd confers nitric oxide resistance to Escherichia coli.

By Maria G. Mason, Mark Shepherd, Peter J. Nicholls, Paul S Dobbin, Kathryn S Dodsworth, Robert K Poole and Chris E Cooper


The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate

Topics: Q
Year: 2009
DOI identifier: 10.1038/nchembio.135
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