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The integration of ‘omic’ disciplines and systems biology in cattle breeding

By Donagh P. Berry, Kieran G Meade, Michael Paul Mullen, Stephen T. Butler, Michael G. Diskin, Dermot G. Morris and Christopher J. Creevey


peer-reviewedEnormous progress has been made in the selection of animals, including cattle, for specific traits using traditional quantitative genetics approaches. Never the less, considerable variation in phenotypes remains unexplained, and therefore represents potential additional gain for animal production. In addition, the paradigm shift in new disciplines now being applied to animal breeding represents a powerful opportunity to prise open the ‘black box’ underlying the response to selection and fully understand the genetic architecture controlling the traits of interest. A move away from traditional approaches of animal breeding toward systems approaches using integrative analysis of data from the ‘omic’ disciplines represents a multitude of exciting opportunities for animal breeding going forward as well as providing alternatives for overcoming some of the limitations of traditional approaches such as the expressed phenotype being an imperfect predictor of the individual’s true genetic merit, or the phenotype being only expressed in one gender or late in the lifetime of an animal. This review aims to discuss these opportunities from the perspective of their potential application and contribution to cattle breeding. Harnessing the potential of this paradigm shift also poses some new challenges for animal scientists – and they will also be discussedM.P. Mullen was funded by a grant from Science Foundation Ireland (07/SRC/B1156)

Topics: "omic", Systems biology, breeding, Application
Publisher: Cambridge University Press
Year: 2010
DOI identifier: 10.1017/S1751731110002120
OAI identifier:
Provided by: T-Stór

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