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Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations

By Mairead L Bermingham, Susan Brotherstone, Donagh P. Berry, Simon J More, Margaret Good, Andrew R Cromie, Ian MS White, Isabella Higgins, Mike Coffey, Sara H Downs, Elizabeth J Glass, Stephen C Bishop, Andy P Mitchell, Richard S Clifton-Hadley and John A Woolliams

Abstract

peer-reviewedBackground: Here, we jointly summarise scientific evidence for genetic variation in resistance to infection with Mycobacterium bovis, the primary agent of bovine tuberculosis (TB), provided by two recent and separate studies of Holstein-Friesian dairy cow populations in Great Britain (GB) and Ireland. Methods: The studies quantified genetic variation within archived data from field and abattoir surveillance control programmes within each country. These data included results from the single intradermal comparative tuberculin test (SICTT), abattoir inspection for TB lesions and laboratory confirmation of disease status. Threshold animal models were used to estimate variance components for responsiveness to the SICTT and abattoir confirmed M. bovis infection. The link functions between the observed 0/1 scale and the liability scale were the complementary log-log in the GB, and logit link function in the Irish population. Results and discussion: The estimated heritability of susceptibility to TB, as judged by responsiveness to the SICTT, was 0.16 (0.012) and 0.14 (0.025) in the GB and Irish populations, respectively. For abattoir or laboratory confirmation of infection, estimates were 0.18 (0.044) and 0.18 (0.041) from the GB and the Irish populations, respectively. Conclusions: Estimates were all significantly different from zero and indicate that exploitable variation exists among GB and Irish Holstein Friesian dairy cows for resistance to TB. Epidemiological analysis suggests that factors such as variation in exposure or imperfect sensitivity and specificity would have resulted in underestimation of the true values.Welsh Assembly Government; Department of Agriculture, Food and Forestry, Ireland Eradication of Animal Disease Board; Biotechnology and Biological Sciences Research Council (grant BB/E018335/2); The Roslin Institute Strategic Programme

Topics: Bovine tuberculosis, Holstein-Friesian, Epidemiology
Publisher: Biomed Central
Year: 2011
DOI identifier: 10.1186/1753-6561-5-S4-S15
OAI identifier: oai:t-stor.teagasc.ie:11019/267
Provided by: T-Stór

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Citations

  1. (2006). Bovine tuberculosis in the European Union and other countries: current status, control programmes and constrains to control. GVJ
  2. (2006). Clifton-Hadley RS: Ante mortem diagnosis of tuberculosis in cattle: A review of the tuberculin tests, gamma-interferon assay and other ancillary diagnostic techniques. Res Vet Sci doi
  3. (2000). Collins JD: Factors associated with the risk of, and animal-level response to,
  4. (2004). Collins JD: The effect of the tuberculin test and the consequences of a delay in blood culture on the sensitivity of a gamma-interferon assay for the detection of Mycobacterium bovis infection in cattle. Vet Immunol Immunopathol doi
  5. (2009). DP: Genetics of tuberculosis in Irish Holstein-Friesian dairy herds. doi
  6. (2002). LG: Genetic parameters of dairy character, protein yield, clinical mastitis and other diseases in the Danish Holstein cattle. doi
  7. (1998). Marenkov VG: Genetics of cattle resistance to tuberculosis.
  8. (2000). Schukken YH: Genetic variation of susceptibility to Mycobacterium avium subsp. paratuberculosis infection in dairy cattle. doi
  9. (2010). SJ: Genetic variation in serological response to Mycobacterium avium subspecies paratuberculosis and its association with performance in Irish HolsteinFriesian dairy cows. Livest Sci doi
  10. (1997). Survival Analysis Using the SAS® System. A practical guide. doi
  11. (2006). The tuberculosis control programme in Ireland: A review of scientific and policy advances since 1988. Vet Microbiol doi
  12. (2010). Woolliams JA: Evidence of genetic resistance of cattle to infection with Mycobacterium bovis. doi

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