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Energetics of Hydride Transfer Reactions in Quinone Reductase 2

By Yer Yang, Thomas G. Bartholow and Michael A. North


Color poster with text, images, diagrams, charts, graphs, and tables.Quinone Reductases belong to the class of flavin-dependent oxidoreductases. With its redox active cofactor flavin adenine dinucleotide (FAD), quinone reductases are known to utilize a ping pong kinetic mechanism during catalysis in which a hydride is swapped back and forth between flavin and its two substrates. The objectives of this study were: to explore the energetics of the ping pong kinetics in NQO2; to examine the conformational changes and free energy change due to substrate shuttling; and to determine the best functional to calculate the electron interaction.University of Wisconsin--Eau Claire Office of Research and Sponsored Programs

Topics: Chemical kinetics, Quinone, Flavins, Oxidoreductases, Posters
Year: 2012
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