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RESEARCH ARTICLE Open Access

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Empirical study of correlated survival times for recurrent events with proportional hazards margins and the effect of correlation and censoring Rodrigo Villegas1*, Olga Julià2 and Jordi Ocaña3 Background: In longitudinal studies where subjects experience recurrent incidents over a period of time, such as respiratory infections, fever or diarrhea, statistical methods are required to take into account the within-subject correlation. Methods: For repeated events data with censored failure, the independent increment (AG), marginal (WLW) and conditional (PWP) models are three multiple failure models that generalize Cox’s proportional hazard model. In this paper, we revise the efficiency, accuracy and robustness of all three models under simulated scenarios with varying degrees of within-subject correlation, censoring levels, maximum number of possible recurrences and sample size. We also study the methods performance on a real dataset from a cohort study with bronchial obstruction. Results: We find substantial differences between methods and there is not an optimal method. AG and PWP seem t

Year: 2016
OAI identifier: oai:CiteSeerX.psu:10.1.1.865.5044
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