ANewborn With Hydrops, Hydrocephalus, and Ophthalmologic Abnormalities

Abstract

A male infant was born at an estimated gestational age of 34-3/7 weeks to a 24-year-old G3P2A0 mother, with unknown group B Streptococcus carriage status, immunity to rubella, and negative serologies for hepatitis B, syphilis, and human immunodeficiency virus (HIV). Pregnancy was complicated by fetal hydrops, initially detected by ultra-sound 3 weeks prior to delivery. Prenatal magnetic reso-nance imaging (MRI) detected severe polyhydramnios, fetal hydrocephalus, and hydrops with ascites. Evaluation at that time also included a normal karyotype and negative Coombs test. The mother presented to our center in active labor, and Caesarian section was performed. Artificial rupture of membranes at the time of delivery revealed a large amount of clear fluid. The infant initially had a weak cry and was intubated in the delivery room, and he was trans-ferred to the Neonatal Intensive Care Unit. Apgar score