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Letters to the Editor

By Micronutrient Concentrations

Abstract

atherosclerosis in adults with HIV Dear Sir: Falcone et al (1) examined serum micronutrient concentrations along with surrogate markers of atherosclerosis in a cohort of HIV-infected adults. They reported that ‘‘the highest tertile of serum vitamin E concentration was associated with higher common and internal carotid intima-media thickness (c-IMT) and coronary artery calcium (CAC) scores (P, 0.05 for c-IMT and CAC)’ ’ (p 1213). They concluded that ‘‘elevated serum vitamin E concentrations... may increase the risk of cardiovascular complications in HIV-infected adults’ ’ (p 1213). However, we believe that the authors ’ conclusion that vitamin E is adversely affecting atherosclerosis is not convincing, is based solely on associations that cannot establish causation, and has no mechanistic basis. Furthermore, on the basis of current descrip-tions of adverse consequences of highly active antiretroviral therap

Year: 2016
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