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Genetics and population analysis Advance Access publication April 11, 2012 Fast and accurate inference of local ancestry in

By Latino Populations, Yael Baran, Bogdan Pasaniuc, Sriram Sankararaman, Dara G. Torgerson, Christopher Gignoux, Celeste Eng, William Rodriguez-cintron, Rocio Chapela, Jean G. Ford, Pedro C. Avila, Jose Rodriguez-santana, Esteban Gonzàlez Burchard and Eran Halperin


Motivation: It is becoming increasingly evident that the analysis of genotype data from recently admixed populations is providing important insights into medical genetics and population history. Such analyses have been used to identify novel disease loci, to understand recombination rate variation and to detect recent selection events. The utility of such studies crucially depends on accurate and unbiased estimation of the ancestry at every genomic locus in recently admixed populations. Although various methods have been proposed and shown to be extremely accurate in two-way admixtures (e.g. African Americans), only a few approache

Year: 2016
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