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A Study of the Association between SNP8NRG241930 in the 5 ’ End of Neuroglin 1 Gene with Schizophrenia in a Group of Iranian Patients

By Seyed Ali, Mohamad Shariati, M. Sc, Mehrdad Behmanesh, Ph. D and Hamid Galehdari Ph. D


Objective: Neuregulin1 (NRG1) gene is among the most promising candidate genes for schizophrenia. This gene is located on 8p22-p12, a region with a reported linkage to schiz-ophrenia. Several studies have reported an association between schizophrenia and the 5 ′ end polymorphisms in this gene. However, some studies have failed to confirm the role of NRG1 gene in the pathogenesis of schizophrenia. In the current study, we attempt to examine the association of SNP8NRG241930 from the NRG1 gene with schizophrenia in an Iranian population. It is noteworthy that there has been no report on the NRG1 associa-tion with schizophrenia in a population from the Middle East region. Materials and Methods: Genomic DNA samples were obtained via isolation from the peripheral blood cells of 95 unrelated subjects with schizophrenia and 95 matched healthy controls from southwest Iran. SNP8NRG241930 was genotyped by PCR-RFLP using ScaI as a restriction endonuclease enzyme. Association of the SNP with schizophrenia was examined using the chi-square test. The frequency difference of al-leles and genotypes between the two groups were compared. P≤0.05 was considere

Year: 2016
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