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Risk of Breast Cancer After Onset of Type 2 Diabetes Evidence of detection bias in postmenopausal women

By Samantha L. Bowker, Kathryn Richardson Msc, Carlo A. Marra and Jeffrey A. Johnson


OBJECTIVEdTo examine the risk of breast cancer in pre- and postmenopausal women with type 2 diabetes (T2D). RESEARCHDESIGNANDMETHODSdThis was a population-based retrospective co-hort study. Cox regression, stratified by pre- (,55 years) and postmenopausal ($55 years) status, was used to estimate hazard ratios (HRs) for breast cancer, during earlier (0–3 months) and later (3 months to 10 years) time windows after diabetes index date. RESULTSdCompared with women without T2D, HRs for breast cancer were 0.95 (95 % CI 0.48–1.86; P = 0.88) and 1.31 (0.92–1.86; P = 0.14) in pre- and postmenopausal womenwith T2D, respectively, in the early time window, and 0.92 (0.75–1.13; P = 0.45) and 1.00 (0.90–1.11; P = 0.93) in pre- and postmenopausal women with T2D, respectively, in the later time window. CONCLUSIONSdWe observed a trend toward an increased risk of breast cancer in post-menopausal women with T2D, but only in the time period immediately after diabetes index date. Diabetes Care 34:2542–2544, 2011 P revious epidemiologic research sug-gests a modestly elevated risk ofbreast cancer in women with type 2 diabetes (T2D), particularly after meno-pause (1). However, it is unclear whether this increased risk is related to a potential detection bias or increased mammography screening surrounding diabetes onset (2,3). Women with a new diagnosis of T2D may have the advantage of increased screening opportunities, which could tran-spire into more cases of breast cancer being diagnosed in this population. Therefore, we examined the risk of breast cancer in pre- and postmenopausal women with in-cident T2D, during earlier and later time windows after diabetes index date

Year: 2016
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