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Malignant Adenomyoepithelioma of the Breast with Lymph Node Metastasis: A Detailed Immunohistochemical Study

By Article Id, Ahlam A. Awamleh, Mihir Gudi and Sami Shousha


Copyright © 2012 Ahlam A. Awamleh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Malignant adenomyoepithelioma of the breast is a rare tumour with around 30 cases reported in the literature. Metastases associated with these tumours are usually haematogenous. Axillary lymph node metastases are thought to be unusual, and it has been recently suggested that axillary node dissection is not indicated unless clinically palpable. We here present a case of a 63-year-old woman, who developed a malignant adenomyoepithelioma with axillary lymph node metastasis, that included epithelial andmyoepithelial elements, in spite of the absence of clinically enlarged nodes. We suggest that histological examination of axillary sentinel node(s) or node sampling may be worthwhile in this condition. Adenomyoepithelioma of the breast is a benign neo-plasm characterised by biphasic proliferation of epithelial and myoepithelial cells [1]. It resembles adenomyoepithe-lioma of salivary glands as first described by Hamperl [2]. Malignant change can occur rarely in one or both cellular components [3] and can be either a pure myoepithelial car

Year: 2016
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