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RESEARCH ARTICLE Clinical Implications of High-Sensitivity Cardiac Troponin Measurements in Hospitalized Medical Patients

By Gideon Y. Stein, Danny Alon, Roman Korenfeld and Shmuel Fuchs


Background The increased use of high sensitivity cardiac troponins (hs-cTn), have made the diagnosis of non-ST elevation myocardial infarction (MI) challenging, especially in complex medical patients, in whom the clinical presentation of MI is nonspecific and multiple comorbidities as well as non-ischemic acute conditions may account for elevated hs-cTn levels. The aim of this study was to assess the frequency of both elevated hs-cTn levels and dynamic changes in hospitalized patients. Methods and Findings We conducted a retrospective study identifying all patients hospitalized in the Internal Medi-cine Division of Rabin Medical Center, Israel between January 2011 to December 2011, for whom at least one hs-cTn T (hs-cTnT) measurement was obtained. Collected data included patient demographics, acute and chronic diagnosis, hs-cTnT and creatinine levels and date of death. Hs-cTnT levels were obtained in 5,696 admissions and was above the 99th percen-tile (> = 13 ng/L) in 61.6 % of the measurements. A relative change of 50 % or higher was ob

Year: 1371
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