Article thumbnail

An Emerging Mycoplasma Associated with Trichomoniasis, Vaginal Infection and Disease

By Jennifer M. Fettweis, Myrna G. Serrano, Bernice Huang, J. Paul Brooks, Abigail L. Glascock, Nihar U. Sheth, Vaginal Microbiome Consortium, Jerome F. Strauss Iii, Kimberly K. Jefferson and Gregory A. Buck

Abstract

Humans are colonized by thousands of bacterial species, but it is difficult to assess the metabolic and pathogenic potential of the majority of these because they have yet to be cultured. Here, we characterize an uncultivated vaginal mycoplasma tightly associated with trichomoniasis that was previously known by its 16S rRNA sequence as ‘‘Mnola.’ ’ In this study, the mycoplasma was found almost exclusively in women infected with the sexually transmitted pathogen Trichomonas vaginalis, but rarely observed in women with no diagnosed disease. The genomes of four strains of this species were reconstructed using metagenome sequencing and assembly of DNA from four discrete mid-vaginal samples, one of which was obtained from a pregnant woman with trichomoniasis who delivered prematurely. These bacteria harbor several putative virulence factors and display unique metabolic strategies. Genes encoding proteins with high similarity to potential virulence factors include two collagenases, a hemolysin, an O-sialoglycoprotein endopeptidase and a feoB-type ferrous iro

Year: 2014
OAI identifier: oai:CiteSeerX.psu:10.1.1.784.3287
Provided by: CiteSeerX
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • ftp://ftp.ncbi.nlm.nih.gov/pub... (external link)
  • ftp://ftp.ncbi.nlm.nih.gov/pub... (external link)
  • http://citeseerx.ist.psu.edu/v... (external link)

  • To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.

    Suggested articles