Down-regulation of HLA-G Attenuates Cleavage Rate in Human Triploid Embryos

Abstract

Introduction: HLA-G is a major histocompatibility complex (MHC), class Ib mol-ecule that is selectively expressed at the fetal–maternal interface. It is thought to play a role in protecting the fetus from the maternal immune response. Interestingly, the preimplantation embryo development (Ped) gene product Qa-2 is also a mouse MHC class Ib protein that affects cleavage and division of preimplantation mouse embryo

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