Abstract

ati ev pa N-k ee ai natures that shed light on their history, both with regard plored, and better insights into the mutational spectrum Mutvei et al. BMC Cancer (2015) 15:311 DOI 10.1186/s12885-015-1278-xEncyclopedia (CCLE), which contains deep genomics and1Department of Cell and Molecular Biology, SE-171 77 Stockholm, Sweden Full list of author information is available at the end of the articleto internal processes such as defective DNA repair, but also reflecting external processes, such as exposure of cells to ultraviolet light or tobacco smoking [2]. By analyzing the distribution of mutations in individual mutated genes, oncogenes and tumor suppressor genes can increasingly will be important for understanding how deregulation of a signaling pathway contributes to cancer and, in the long-term, for future therapy development. To gain further insights into the link between Notch signaling and tumor development, we have analyzed the extent of Notch mutations in tumor cell lines, using in-formation from the recently published Cancer Cell Line * Correspondence