Hospital buildings are of great importance after any natural calamity such as earthquake. The structural and non-structural components should remain operational and safe after earthquake. So to mitigate the effect of earthquake on the structure the base isolation technique is the best alternative as a seismic protective system. The basic idea of base isolation system is to reduce the earthquake induced inertia forces by increasing the fundamental period of the structure. The aim of this study is the use of High density rubber bearing (HDRB) and friction pendulum system (FPS) as an isolation device and then to compare various parameters between fixed base condition and base isolated condition by using SAP2000v14 software. In this study the (G+12) storey hospital building is used as a test model. Nonlinear time history analysis is carried out for both fixed base and base isolated structure. The result obtained shows the reduction in base shear in both direction and increase in the displacement and time period for the base isolated structure
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