DOI: 10.2298/AVB0903147C UDK 619:612.018.2 EFFECT OF SINGLE DOSE DEXAMETHASONE ADMINISTRATION ON METABOLISM RELATED PARAMETERS IN LACTATING FAT TAILED SHEEP

Abstract

This study was designed to investigate the effect of a single dose glucocorticoid administration on the parameters related to energy metabolism in sheep. Forty healthy lactating fat tailed ewes, 2-3 years old, were obtained from the Farm of the University of Kafkas. The animals were divided into control (n=20) and treated group (n=20). Ewes in the treatment group (n=20) was parenterally given a single dose of 0.025 mg/kg dexamethasone (Deksavet %0.4 enj.®, Interhas, Istanbul-Turkey) at the beginning of the study. Ewes in the control group (n=20) were parenterally given the same dose of placebo at the beginning of the study. All animals were blood sampled before the drug administration and on the 1st, 2nd, 3rd, 4th, 5th and 7th day of injection. Sera samples were analysed for the determination of concentrations of insulin, -hydroxybutyric acid (BHB), non esterified fatty acid (NEFA), glucose, triglycerides, cholesterol, aspartate aminotransferase (AST), total protein, albumin, globulin and phosphorus. Cholesterol, glucos

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